Association Between Biomarkers and eGFR Decline in Pulmonary Hypertension

Pulmonary Hypertension Clinical Trial

Official title: Association Between Biomarkers and Decline in Estimated Glomerular Filtration Rate in Patients With Pulmonary Hypertension

Status Recruiting

Clinical Trial Summary

The objective of this study is to examine the association between urinary and plasma biomarkers and the change of estimated glomerular filtration rate (eGFR) in patients with pulmonary hypertension (PH) as a tool to identify patients at high risk for short-term eGFR decline.

Clinical Trial Description

PH is a severe, progressive disease associated with right ventricular dysfunction, right-sided heart failure (HF) and death. Chronic kidney disease (CKD) is approximately 35% in patients with PH, and its presence is associated with an enhanced risk for adverse outcomes, with the risk increasing incrementally with declining kidney function. Poor right ventricular function may increase venous congestion, alter ventricular interdependence, decrease effective cardiac output and activate the renin-angiotensin- aldosterone system, thereby aggravating kidney disease. To date, biomarkers for assessment of CKD progression in PH are lacking. The objective of this study is to examine the association between urinary and plasma biomarkers and the change of eGFR in patients with PH, aiming to identify those at high risk for short-term eGFR decline. ;

Related Conditions & MeSH terms

• Hypertension
• Hypertension, Pulmonary
• Pulmonary Hypertension

• NCT number: NCT06409624
• Study type: Observational
• Source: University of Giessen
• Contact: Faeq Husain-Syed, MD
• Phone: +49 641 985 42378
• Email: faeq.husain-syed@innere.med.uni-giessen.de
• Status: Recruiting
• Start date: May 2024
• Completion date: July 2026