Pulmonary Hypertension Clinical Trial
Official title:
Evaluation of Echocardiographic Indices and Blood Biomarkers in Group 1 Pulmonary Hypertension
- To evaluate different echocardiographic indices in diagnosis and follow up of group 1
pulmonary hypertension.
- To evaluate blood biomarkers (troponin, uric acid and micro RNA) in naïve group 1
pulmonary hypertension.
Status | Not yet recruiting |
Enrollment | 35 |
Est. completion date | April 2023 |
Est. primary completion date | March 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: 1. Age>18 years old 2. Patient diagnosed as group 1 PH. Exclusion Criteria: 1. Age under 18 years. 2. Unwilling or unable to sign the informed consent form. 3. Hemodynamically unstable condition requiring inotropic or vasoactive drugs. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Bendayan D, Shitrit D, Ygla M, Huerta M, Fink G, Kramer MR. Hyperuricemia as a prognostic factor in pulmonary arterial hypertension. Respir Med. 2003 Feb;97(2):130-3. — View Citation
Crosswhite P, Sun Z. Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension. J Hypertens. 2010 Feb;28(2):201-12. doi: 10.1097/HJH.0b013e328332bcdb. Review. — View Citation
Filusch A, Giannitsis E, Katus HA, Meyer FJ. High-sensitive troponin T: a novel biomarker for prognosis and disease severity in patients with pulmonary arterial hypertension. Clin Sci (Lond). 2010 Jun 2;119(5):207-13. doi: 10.1042/CS20100014. — View Citation
Simonneau G, Galiè N, Rubin LJ, Langleben D, Seeger W, Domenighetti G, Gibbs S, Lebrec D, Speich R, Beghetti M, Rich S, Fishman A. Clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):5S-12S. Review. — View Citation
Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, Williams PG, Souza R. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019 Jan 24;53(1). pii: 1801913. doi: 10.1183/13993003.01913-2018. Print 2019 Jan. — View Citation
Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ. Mechanisms of right heart failure-A work in progress and a plea for failure prevention. Pulm Circ. 2013 Jan;3(1):137-43. doi: 10.4103/2045-8932.109957. — View Citation
Voelkel NF, Tuder RM. Cellular and molecular biology of vascular smooth muscle cells in pulmonary hypertension. Pulm Pharmacol Ther. 1997 Oct-Dec;10(5-6):231-41. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation of echocardiographic indices in Group 1 pulmonary hypertension | All trans thoracic echocardiographic indices will be measured: peak tricuspid regurgitation velocity (m/s). right ventricular outflow acceleration time (msec). peak early pulmonary regurgitation velocity (m/s). peak late pulmonary regurgitation velocity (m/s) . tricuspid regurgitation time velocity integral (m/s). tricuspid annulus tissue Doppler image . right ventricle morphology and functions. left ventricle morphology and functions. |
baseline | |
Primary | Evaluation of serum troponin level in Group 1 pulmonary hypertension | Blood samples from pulmonary circulation will be obtained for troponin level | baseline | |
Primary | Evaluation of serum uric acid in Group 1 pulmonary hypertension | Blood samples from pulmonary circulation will be obtained for serum uric acid. | baseline | |
Secondary | Evaluation of mRNA level in Group 1 pulmonary hypertension | Blood samples from pulmonary circulation will be obtained for mRNA level | baseline |
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