Sildenafil in Hemodialysis Patients With Pulmonary Hypertension

Status Active, not recruiting

Clinical Trial Summary

Sildenafil is a phosphodiesterase inhibitor that can exert a nitric oxide-mediated vasodilation effect, so it's considered one of the preferred agents especially in hypoxia induced pulmonary hypertension, can achieve pulmonary vasodilation by enhancing sustained levels of cyclic guanosine monophosphate (cGMP) and nitric oxide.

Despite the potential burden of pulmonary hypertension in hemodialysis patients, such agent like sildenafil has limited studies about optimum dose, safety and long term efficacy in End stage renal disease patients on hemodialysis with pulmonary hypertension

Clinical Trial Description

1- To evaluate the effect of sildenafil on pulmonary artery pressure and right ventricular function in hemodialysis patients with pulmonary hypertension.

1. Primary outcome:

● Reduction in estimated Pulmonary Artery pressure value (ePAP) in mmHg via transthoracic Doppler Echocardiography.

2. Secondary outcomes:

- Detection of safety of sildenafil in hemodialysis patients.

- Finding out sildenafil's optimum dose for hemodialysis patients with pulmonary hypertension. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03763045
Study type	Interventional
Source	Ain Shams University
Contact
Status	Active, not recruiting
Phase	Phase 2/Phase 3
Start date	December 2, 2018
Completion date	February 28, 2019

View Details

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