Pulmonary Hypertension Clinical Trial
Official title:
A Case Control Study of the Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Diseases, and Correlation Between Patients Epidemiologic and Clinical Status and the Development of Pulmonary Hypertension.
Pulmonary hypertension (PH) is defined as a group of diseases characterised by an elevated
mean pulmonary artery pressure (Ppa) ≥25 mmHg at rest. Recently, chronic myeloproliferative
diseases (CMPD) associated with pulmonary hypertension were included in the group 5
category, corresponding to PH for which the aetiology is unclear and/or multifactorial. CMPD
include chronic myelogenous leukaemia, chronic neutrophilic leukaemia and chronic
eosinophilic leukaemia (which primarily express a myeloid phenotype and polycythaemia vera),
idiopathic myelofibrosis, and essential thrombocytosis in which erythroid or megakaryocytic
hyperplasia predominates.
The purpose of this research:
1. Assess Prevalence of PH in patients with CMPD in Northern Israel
2. Describe the demographics and clinical course in patients with CMPD who are diagnosed
with PH.
study will include the following:
- sex
- age
- BMI
- ethnicity
- age diagnosed with Myeloproliferative disease
- clinical manifestations of the myeloproliferative disease
- JAK2 mutation
- known hematological complications
;
Observational Model: Case Control, Time Perspective: Retrospective
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