Pulmonary Hypertension Clinical Trial
Official title:
Noninvasive Determination Of Cerebral Tissue Oxygenation And Cerebral Blood Flow With Near-Infrared Spectroscopy In Patients With Pulmonary Hypertension Undergoing Right Heart Catheterization
To study the effect of acute pulmonary vasodilatation on cerebral tissue oxygenation (CTO)
and cerebral blood flow (CBF) as indicator for cerebrovascular autoregulation in comparison
to the effects of supplemental oxygen, decreased carbon dioxide by hyperventilation and
exercise in patients with pulmonary hypertension (PH) undergoing clinically indicated right
heart catheterisation (RHC).
Oxygenation and hemodynamic parameters will be assessed during RHC according to standard
procedures. Non-invasive near infrared spectroscopy (NIRS) and a nasal canula will be
additionally applied to measure CTO, CBF and endtidal CO2 (EtCO2). All parameters will be
obtained at rest breathing room air, during an oxygen challenge, during standardized
hyperventilation, under vasodilatation testing and during exercise in random, single-blinded
sequences (except for exercise and hyperventilation). Pulmonary, systemic and cerebral
oxygenation parameters and hemodynamics will be correlated with each other and functional
class, quality of life, exercise and cognitive assessments at the time of the RHC and after
three month.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Diagnostic
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