Pulmonary Hypertension Clinical Trial
Official title:
Randomized, Prospective Investigation on the Effects of Immunoadsorption on Pulmonary Vascular Resistance in Patients With Pulmonary Hypertension
The purpose of this study is to investigate, if Immunoadsorption of autoantibodies with subsequent substitution of immunoglobulins is able to improve haemodynamics in patients with pulmonary hypertension.
Increased pulmonary precapillary vascular resistance due to vasoconstriction and
vasoproliferative processes is the basic pathophysiological mechanism in the development of
pulmonary hypertension (PH). In patients with pulmonary arterial hypertension (PH)
production of endothelin-1 (ET-1) is increased and elevated ET-1 plasma levels correlate
with PH severity As recently shown Autoantibodies against the Endothelin-1 Typ A and
Angiotensin II Typ-1 Receptor, which have a high Incidence in PH-Patients, may also play an
important role in the pathophysiology of PH (Dandel et al.).
The concept of this study is that the elimination of these autoantibodies by
Immunoadsorption with protein A may improve haemodynamics and patient wellbeing.
Immunoglobulins are substituted after Immunoadsorption to minimize infection risk.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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