Pulmonary Embolism Clinical Trial
— BIODINEROfficial title:
Prognostic Value of Novel Biomarkers in Patients With Shortness of Breath Attending an Emergency Department
The purpose of this study is to evaluate the capacity of some novels biomarkers Procalcitonin (PCT), Midregional Proadrenomedullin (MR pro ADM), Midregional pro-atrial natriuretic peptide (MR pro ANP), Copeptin (CT pro arginine vasopressin), Pro endothelin to stratify the risk in severe dyspnea.
Status | Completed |
Enrollment | 444 |
Est. completion date | September 2011 |
Est. primary completion date | August 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - tachypnea > 25 /min or Pa02 < 70 mmHg or SpO2 < 93% - diagnosis suspected: CAP, PE,EACOPD, AHF Exclusion Criteria: - other cause of dyspnea, - unreachable on Day 30 |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
France | Emergency department of Pitié Salpetriere Hospital | Paris |
Lead Sponsor | Collaborator |
---|---|
ThermoFisher Scientific Brahms Biomarkers France |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | prognostic value of PCT, MR proADM, Mr pro ANP, Copeptin and pro endothelin in SOB | all cause mortality or Intensive Care Unit(ICU) admission from inclusion to Day 30 | at Day 30 | No |
Secondary | establish the diagnostic value of PCT and MR pro ANP | Confirm the diagnostic value of PCT and it's level in sepsis and MR pro ANP in Heart failure | at admission | No |
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