Safety Study of Inhaled Saline in Acute Lung Injury

Status Withdrawn

Clinical Trial Summary

To determine if an inhaled hypertonic saline solution has any effect on lung function in patients with acute respiratory distress syndrome (ARDS).

Clinical Trial Description

Hypertonic Saline (HS) aerosols have proven efficacious mucolytics in patient with cystic fibrosis and are well tolerated in that population. Safety concerns in mechanically ventilated patients with ARDS center primarily on HS's effects on lung water distribution (intra vs. extra alveolar) and on airway reactivity. For that reason we plan a small feasibility trial with narrowly focused physiologic endpoints, namely to measure the effects of a single 5ml dose of 7% Saline aerosol on blood gas tensions, hemodynamics and the static and dynamic properties of the relaxed respiratory system. This narrowly scoped study is to lay the foundation for a larger multicenter intervention trial. ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Acute Lung Injury
Lung Injury
Pulmonary Edema
Respiratory Distress Syndrome, Adult

Clinical Trial Details

NCT number	NCT01713595
Study type	Interventional
Source	Mayo Clinic
Contact
Status	Withdrawn
Phase	Phase 1
Start date	October 2013
Completion date	May 2015

View Details

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