Hyperandrogenism Clinical Trial
Official title:
Assessment of Day-night Secretion of Progesterone and LH Across Pubertal Maturation in Girls With and Without Hyperandrogenemia (JCM023)
Hormones are substances that are made by the body and are sent directly out into the bloodstream to increase or decrease the function of certain organs, glands, or other hormones. Testosterone is a hormone found in the blood of all girls, but some girls have too much testosterone in their blood. Too much testosterone in the blood can possibly lead to a problem called polycystic ovary syndrome (PCOS). People with PCOS have abnormal menstrual periods, excess facial and body hair, and too much testosterone in their blood. On the other hand, some girls with too much testosterone in their blood do not develop PCOS. We do not know why some of these girls develop PCOS and why some do not. The purpose of this research study is to find out whether too much testosterone can cause problems with other hormones that can lead to the development of PCOS. This study may help us understand more about the causes of PCOS.
Polycystic ovary syndrome (PCOS) is a common disorder marked by irregular ovulation and hyperandrogenism. Hyperandrogenemia during adolescence can be a forerunner of adult PCOS. However, the progression of hormonal abnormalities leading to PCOS are unclear. We will examine hormonal profiles (e.g., LH, FSH, progesterone, testosterone, estradiol) during pubertal maturation in adolescent girls with and without elevated plasma androgens. The working hypothesis is that, in pubertal girls without hyperandrogenemia, overnight rises of progesterone are associated with a reduction of LH frequency during the waking morning hours. However, in pubertal girls with hyperandrogenemia, LH frequency will be higher than normal during both the day and night, despite similar or higher progesterone levels. The studies will involve frequent blood sampling over 18 hours. We will assess differences in hormone parameters between time blocks (1900-2300 h, 2300-0300 h, 0300-0700 h, 0700-1100 h) in individuals to evaluate day-night changes. We will compare such changes between those with hyperandrogenemia and those without hyperandrogenemia. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05112029 -
Metabolic Profile and Adipokine Levels in Young Hyperandrogenemic Females
|
||
Terminated |
NCT01428193 -
Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
|
N/A | |
Enrolling by invitation |
NCT04485403 -
The Effect of Ibuprofen on Women With PCOS.
|
Phase 2 | |
Active, not recruiting |
NCT00930007 -
Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone
|
||
Completed |
NCT03252223 -
Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS
|
Phase 4 | |
Terminated |
NCT02523898 -
Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant
|
Phase 2 | |
Recruiting |
NCT04723862 -
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?
|
Early Phase 1 | |
Suspended |
NCT02611128 -
Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia
|
||
Recruiting |
NCT04453306 -
Treatment of Obesity With Topiramate in Patients With Polycystic Ovary Syndrome
|
Phase 4 | |
Recruiting |
NCT04979377 -
Prevalence of Hyperandrogenism in Type 1 Diabetes
|
||
Recruiting |
NCT05926115 -
Phenotype and Epidemiology of the Polycystic Ovary Syndrome (PCOS) in Colombia (PEP - Colombia) Study.
|
||
Active, not recruiting |
NCT01569425 -
Meal Timing on Glucose Metabolism and Hyperandrogenism in Lean Women With Polycystic Ovary Syndrome
|
N/A | |
Recruiting |
NCT01428089 -
Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone
|
Phase 1 | |
Active, not recruiting |
NCT01421810 -
Ovarian Contribution to Androgen Production in Adolescent Girls
|
N/A | |
Completed |
NCT01313455 -
Adrenal Hyperplasia Among Young People With PCOS
|
||
Completed |
NCT03188640 -
Bariatric Surgery, Hormones, and Quality of Life
|
N/A | |
Not yet recruiting |
NCT02402413 -
Ultrasound Three-dimensional Characterization of Ovarian Morphology in Women With Polycystic Ovary Syndrome (PCOS)
|
N/A | |
Completed |
NCT02651636 -
Combined Therapy With Myo-inositol and Alpha-Lipoic Acid in PCOS Women
|
N/A | |
Recruiting |
NCT00929006 -
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism
|
Early Phase 1 | |
Not yet recruiting |
NCT00665171 -
Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome
|
N/A |