PTSD Clinical Trial
Official title:
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images.
Status | Recruiting |
Enrollment | 80 |
Est. completion date | June 30, 2026 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility | Inclusion Criteria: - 18 years of age or older - Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement - Willing to provide informed consent and participate in the study - Ability to read and write English fluently Exclusion Criteria: - Unwilling to provide informed consent - Not a native English Speaker - Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement - Pregnant women - Participants with active psychosis - Participants with suicidal ideation - Participants with substance abuse issues |
Country | Name | City | State |
---|---|---|---|
United States | University of California Los Angeles | Los Angeles | California |
Lead Sponsor | Collaborator |
---|---|
University of California, Los Angeles | National Institutes of Health (NIH), NeuroPace, VA Greater Los Angeles Healthcare System |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Physiological change - eye-blinks | Eye blinks will be measured using an eye tracking device and will be measure in blinks per second. | during the intervention/behavioral tasks with and without stimulation | |
Primary | Physiological change - heart rate variability | heart rate variability will be measured in milliseconds. | during the intervention/behavioral tasks with and without stimulation | |
Primary | Physiological change - skin conductance | Skin conductance will be measured in microSiemens. | during the intervention/behavioral tasks with and without stimulation | |
Primary | Neurophysiological activity | Neurophysiological activity will be measured in Hz | during the intervention/behavioral tasks with and without stimulation |
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