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Neuroimaging Memories of Fear and Safety in the Human Brain

PTSD Clinical Trial

Official title:
Localizing and Modulating Competing Memories of Fear and Safety in the Human Brain

Clinical Trial Summary

The purpose of this research is to use functional magnetic resonance imaging (fMRI) to investigate how the brain forms associations between neutral and negative stimuli. The ultimate goal is to understand the neural systems involved in regulating negative emotional responses to fearful stimuli.

Clinical Trial Description

This study uses functional magnetic resonance imaging (fMRI) to investigate how the brain forms associations between neutral stimuli and a mildly uncomfortable electrical stimulation to the wrist. Referred to as Pavlovian fear conditioning. The goal is to compare brain activity between individuals with posttraumatic stress disorder (PTSD) and healthy control subjects without PTSD. PTSD is characterized by excessive fear and anxiety, including in harmless situations. The data here will help us better understand dysregulation in neural circuitry involved in fear recovery, which has implications for improving treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04975009
Study type Interventional
Source University of Texas at Austin
Contact
Status Recruiting
Phase N/A
Start date July 12, 2021
Completion date December 31, 2025
View Details
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