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Prolonged Exposure and Oxytocin

PTSD Clinical Trial

Official title:
Augmenting Prolonged Exposure Therapy for PTSD With Intranasal Oxytocin

Clinical Trial Summary

Posttraumatic stress disorder (PTSD) is a chronic, debilitating anxiety disorder that may develop after direct or indirect exposure to traumatic events. Prolonged Exposure (PE) is a cognitive-behavioral psychotherapy modality with a wealth of empirical support demonstrating its efficacy to treat PTSD in a variety of populations. The neuropeptide oxytocin is a promising new pharmacotherapeutic agent with prominent anxiolytic effects . Despite a strong biological and theoretical rationale for investigating the potential effectiveness of augmenting PE with intranasal oxytocin, no studies to date have done so. The current study aims to address this important gap in the literature by examining changes in PTSD symptoms following PE treatment combined with a) 40 IU of intranasal oxytocin or b) placebo.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03238924
Study type Interventional
Source Medical University of South Carolina
Contact
Status Completed
Phase Phase 2
Start date January 1, 2015
Completion date December 31, 2016
View Details
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