Psoriatic Arthritis Clinical Trial
Official title:
A Pilot Study to Evaluate the Utility of Thermography in Assessing Response to Golimumab Treatment in Psoriatic Arthritis
This study will be an open label pilot study to explore the utility of thermography in assessing response to Golimumab treatment in Psoriatic Arthritis (PsA). Ten patients fulfilling the Classification criteria for Psoriatic Arthritis (CASPAR) for Psoriatic Arthritis with active disease and eligible for anti-TNF therapy will be invited to participate in this study. They will be assessed at 4 time points during the study: prior to their first anti-TNF medication (screening and basal visits), and subsequently within 5 days after their 2nd and 4th doses of monthly Golimumab.
Psoriatic Arthritis is a joint problem (arthritis) that often occurs with a skin condition
called psoriasis. Psoriasis is a common skin problem that causes red patches on the body, and
it is an on-going (chronic) inflammatory condition. About 1 in 20 people with psoriasis will
develop arthritis with the skin condition. In most cases, psoriasis comes before the
arthritis. The cause of Psoriatic Arthritis is not known.
Psoriatic Arthritis can be treated using different types of drugs to reduce pain and swelling
of the joints. New medicines that block an inflammatory protein called tumor necrosis factor
(TNF) are being widely used for progressive Psoriatic Arthritis, as is the case of the drug
Golimumab.
Thermography is the use of images to study heat distribution in different parts of the body,
and allows one to see variations in temperature, for example in detecting joint inflammation.
This is a pilot study to evaluate whether thermography is able to reliably detect joint
inflammation in Psoriatic Arthritis, and whether it is able to detect improvement or
worsening in inflammation during medical treatment with Golimumab. This involves assessing
disease activity using some questionnaires, examining of patient joints, performing blood
tests, ultrasound and thermography.
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