Psoriasis Clinical Trial
Official title:
Studying the Effect of Methotrexate Alone Versus Methotrexate and Vitamin D on the Cardiovascular Risk of Psoriatic Patients
The prevalence of cardiovascular risk in psoriasis has been reported in previous
studies.Various studies have also shown that systemic treatments for psoriasis, including
methotrexate, may significantly decrease this cardiovascular risk. We proposed that the
addition of vitamin D may not only improve the therapeutic effect of various treatment
modalities but also increase its effect on decreasing the cardiovascular risk in psoriasis.
So our aim of work is to assess the Clinical improvement and cardiovascular risks in
psoriatic patients after treatment with methotrexate alone with the dose of 0.2-0.5
mg/kg/week for three months in comparison to combined methotrexate with the same dose and
vitamin D injection with the dose of 200,000 IU per month for 3 months.
Each patient will do the following before starting treatment& after 3 months:
1. Fasting blood sugar, 2 hours postprandial and glycosylated hemoglobin
2. Liver and Kidney function tests.
3. Cardiovascular risk assessment by measuring the intima media thickness of carotid
arteries using Carotid duplex and High sensitive C reactive protein measuring by
particle-enhanced immunonephelometry on autoanalyzer.
4. Lipid profile (HDL, LDL, cholesterol and triglycerides).
5. Calculate body mass index and measure blood pressure
6. Albumin /creatinine ratio
7. Serum vitamin D level. Clinical response will be evaluated by Psoriasis Area and
Severity index (PASI) & Psoriasis Disability Index (PDI) scores before and after 3
months of treatment
n/a
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