Psoriasis Clinical Trial
Official title:
Atorvastatin to Reduce Psoriasis Severity and Improve Endothelial Function in Patients With Severe Psoriasis and Non-Elevated LDL Levels: A Randomized, Double Blind, Placebo-Controlled Study.
Patients with psoriasis seem to have increased risk for developing atherosclerosis. This may
be due to the fact that psoriasis and atherosclerosis are both caused by inflammation and
involvement of cells of the immune system. Atherosclerosis is frequently treated by statins
(class of cholesterol lowering drugs), which lower bad cholesterol levels and also reduce
inflammation. Some new evidences also suggest that therapy with statins may improve
psoriasis skin disease.
The current study aims are to evaluate whether a strong statin named Atorvastatin can
improve psoriatic skin disease and functioning of the arteries. The study also aims to
evaluate if the activity of these two diseases are related to levels of common inflammatory
biomarkers (substance in blood) and whether Atorvastatin can change their levels.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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