Psoriasis Clinical Trial
Official title:
Analysis of the Response of Subjects With Atopic Dermatitis to Oral Vitamin D3 by Measurement of Antimicrobial Peptide Expression in Skin and Saliva
This study will examine whether administration of oral Vitamin D3 given over 21 days will change the antimicrobial peptide expression in the skin or saliva of subjects with Atopic Dermatitis (AD). This study will help researchers determine if the lack of the expression of antimicrobial peptides in individuals with AD plays a role in the susceptibility to eczema vaccinatum (EV).
Atopic Dermatitis (AD) is a chronic inflammatory skin disorder in which the skin becomes
extremely itchy and is susceptible to recurrent skin infections. AD is thought to occur from
a combination of immunological, genetic, and environmental factors. Individuals with AD are
at risk for developing a severe and widely disseminated infection called eczema vaccinatum
(EV). EV is caused when the live attenuated vaccinia virus in the vaccine reproduces and
spreads throughout the body. Individuals with AD lack certain antimicrobial peptides,
specifically cathelicidins.
This trial also includes a sub-study with individuals who have psoriasis. Psoriasis is also
an immune-mediated skin disease, and is characterized by scaling skin and inflammation
(pain, swelling, heat, and redness). Most psoriasis cause patches of thick, red skin with
silvery scales. These patches can itch or feel sore. This sub-study will provide additional
information on psoriatic responses to oral vitamin D. (Originally listed separately as
ADVN-CATH-03-01, NCT: 01078259ID.)
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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