The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection

Prosthetic Joint Infection Clinical Trial

Official title: The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection

Status Enrolling by invitation

Clinical Trial Summary

This is a prospective multicenter study. All patients presenting for revision hip or knee arthroplasty for all indications under the respective surgeon's care may be eligible. Per standard of care preoperatively, all patients must have blood drawn for erythrocyte sedimentation rate(ESR), C-reactive protein(CRP) and D-dimer. Aspiration of the joint in question may be performed at the discretion of the treating surgeon and results documented. Intraoperative samples will also be collected and sent for NGS analysis

Clinical Trial Description

Pre-operative D-dimer testing should be performed if this is in keeping with the local institutional standard of care. Otherwise, D-dimer testing will be omitted from the pre-operative panel of tests collected.

NGS results will be made available to the Investigator. Treatment will remain within keeping with the Investigator's standard of care. NGS results may be used at the discretion of the treating surgeon in guiding patient treatment. ;

Related Conditions & MeSH terms

• Arthritis, Infectious
• Communicable Diseases
• Infection
• Prosthetic Joint Infection

• NCT number: NCT03200470
• Study type: Observational
• Source: Rothman Institute Orthopaedics
• Status: Enrolling by invitation
• Phase: N/A
• Start date: February 16, 2017
• Completion date: March 2018