Prosthetic Joint Infection Clinical Trial
Official title:
Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint Infection
Chronic prosthetic joint infection (PJI) is a devastating complication of arthroplasty and
its treatment continues to fuel the debate on how to manage it appropriately.
One stage and two stage exchange surgery both are the conventional surgical procedures for
chronic PJI commonly used to date.
Two stage surgery disadvantages (major surgery, anesthesia and nosocomial risks, functional
impairment between surgeries and a high socio-economic coast) encouraged many surgical teams
to adopt one stage exchange surgery which provides equivalent or better outcomes. However one
stage surgery encounters a major conceptual difficulty when it comes to implant the new
prosthesis in a surgical site microbiologically undetermined and potentially contaminated.
Investigators suppose the new prosthesis is implanted in a contaminated setting regardless of
bacteria type and antibiotic therapy duration before arthroplasty.
The total lack of data answering this question motivated the conception of this prospective
study in order to describe the microbiological setting where is implanted the new prosthesis
with one stage exchange surgery after surgical excision and antibiotic therapy initiation in
chronic PJI.
Study duration: Two weeks. Recruitment period: 18 months. Maximal duration of data collection: Two weeks. Investigator center: monocenter study. Mean patient inclusion per year: 70 patients per year. ;
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