Prostatic Neoplasms Clinical Trial
Official title:
A Phase II Study of Degarelix in the Management of Non-Metastatic Hormone-Refractory Prostate Cancer
This study is being offered to patients who have hormone resistant prostate cancer (HRPC).
This means that their prostate cancer is no longer responding to standard hormonal therapy.
The purpose of this study is to determine whether Degarelix will be able to stop the PSA from
rising in patients with hormone resistant prostate cancer.
This is a phase II study of a GnRH antagonist drug, Degarelix, for use in hormone resistant
prostate cancer patients who have had biochemical PSA progression despite the use of total
androgen blockade therapy. Patients will receive at least six monthly injections of Degarelix
unless the patient shows radiographic or symptomatic disease progression, intolerable
toxicity or decides to withdraw from the study. Patients will be evaluated for measures of
efficacy, toxicity and disease progression during treatment and afterwards until
radiologically confirmed metastatic disease progression or until the patient is removed from
the study.
Overall objective:
The efficacy of Degarelix as a treatment for HRPC will be evaluated
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