Prostatic Neoplasms Clinical Trial
Official title:
A Cross-Sectional Study of Erectile Dysfunction in Patients With Locally Advanced Prostate Cancer Who Have Undergone Radiotherapy and Prolonged Pharmacological Androgen Ablation
The optimal duration of hormonal therapy is yet to be determined in the treatment of locally
advanced carcinoma of the prostate. The RTOG performed a trial of 4 months of neoadjuvant
and concurrent hormones(consisting of Goserelin and Flutamide) compared to radiation alone,
and found that there was an improvement in local control and progression-free survival, but
no improvement in overall survival. The EORTC performed a similar trial, but used Goserelin
alone for a period of 3 years. This trial showed an improvement in local control,
disease-free survival, and in contrast to the RTOG trial, an improvement in overall
survival.
The rate of erectile dysfunction in men who receive a prolonged period of Gosereline (i.e. 2
yrs) is not known, but suspected according to expert opinion, to be significantly higher
than a shorter course of hormonal ablation. Therefore the price of of a survival advantage
in locally advanced prostate cancer maybe at a cost of increased rates of erectile
dysfunction.
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label
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