Prostate Cancers Clinical Trial
Official title:
Anti-[18F]FACBC PET-CT for the Characterization of Primary Prostate Cancer
The purpose of this research project is to test if a compound (chemical substance) has a
natural tendency to go to prostate cancer. This compound has a small amount of radioactivity
attached to it and is called a radiotracer. The name of the radiotracer is FACBC and can be
detected on a special imaging device called a PET scanner (positron emission tomography).
The radiotracer is treated in the body much like an amino acid which is a nutrient required
for normal functioning. Tumors also use these nutrients. Earlier studies have shown that
this radiotracer may be able to detect prostate cancer.
The investigators will perform a study with 20 patients in whom they know have prostate
cancer after a biopsy and who are scheduled for an operation in which the prostate is
removed and the nearby lymph nodes are examined. This operation is called prostatectomy. The
investigators think that this radiotracer can help us determine where exactly the prostate
cancer is present in the prostate or if it has spread. This information may be useful in the
future to help with other non-surgical therapy such as radiation beam therapy.
The investigators will compare the results of the FACBC PET scan to the results of the
pathology analysis of the removed prostate. In this way the investigators can determine how
good a test FACBC PET is for finding out where and if prostate cancer is located in the
prostate or nearby lymph nodes. The investigators will also do more advanced analysis on the
biopsy samples to see if they can tell why FACBC goes into prostate cancer cells.
This radiotracer has been tested in over 100 human subjects without incident. It has also
been chosen by the National Institutes of Health (NIH) as a promising radiotracer. The NIH
is funding this study.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT02810886 -
Prospective Evaluation of 68Ga-PSMA PET-CT for Recurrence Detection of Prostate Cancer and Its Impact on Patient Management
|
Phase 2 |