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Progesterone Resistance clinical trials

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NCT ID: NCT06390904 Recruiting - Obesity Clinical Trials

GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Atypical Hyperplasia Patients

Start date: July 13, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

To investigate the efficacy of Gonadotropin-releasing Hormone Agonist (GnRHa) plus letrozole in obese progestin-insensitive atypical endometrial hyperplasia (EAH) patients.

NCT ID: NCT06379113 Recruiting - Obesity Clinical Trials

GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients

Start date: July 13, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

To investigate the efficacy of GnRHa plus letrozole in obese progestin-insensitive EEC patients.

NCT ID: NCT05316935 Recruiting - Clinical trials for Endometrial Neoplasms

GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients

Start date: July 13, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

To investigate the efficacy of GnRHa plus letrozole vs Diane-35 plus metformin in non-obese progestin-insensitive early-stage endometrial cancer (EEC) and atypical hyperplasia(EAH) patients asking for conservative treatment.

NCT ID: NCT05062135 Completed - Polycystic Ovary Clinical Trials

Progesterone Action on Endometrium of PCOS

Start date: February 10, 2014
Phase: N/A
Study type: Interventional

Objective: To study the influence of metabolic factors on the action of progesterone on the endometrium of women with PCOS. Design: A prospective open-label clinical trial. Setting: Participants were recruited from an outpatient reproductive endocrinology clinic at an academic tertiary medical care center from 2014 to 2019. Subjects: To assess the sole effect of progesterone (P4) on the endometrium we studied amenorrheic (cycles> 90 days) women with PCOS (n=23), comparing them to healthy eumenorrheic control women ( n=13). Intervention(s): All subjects underwent an endometrial biopsy (EB) in the follicular phase of the first study cycle. They were then treated with micronized P4 (400 mg/day x 10 days intravaginally) from days 14-28 of the cycle, and a second EB was performed between days 20-24 of the cycle (second phase). Main Outcome Measure(s): EB samples were analyzed under light microscopy for histomorphometric analysis.

NCT ID: NCT03930212 Completed - Clinical trials for Progesterone Resistance

Progesterone Supplementation in Threatened Abortion

Prothreat
Start date: January 1, 2018
Phase: Phase 4
Study type: Interventional

To decide whether progesterone supplementation in threatened abortion is a sound practice.

NCT ID: NCT03519776 Completed - Clinical trials for Progesterone Resistance

Variation of Progesterone in IVF Cycles

Start date: May 10, 2018
Phase:
Study type: Observational

to examine if a natural daytime variation in progesterone levels may explain parts of the inconsistent findings from studies reporting divergent results concerning this matter and will be carried out by several blood samples from the same patient during the day of ovulation triggering.

NCT ID: NCT03356964 Completed - Clinical trials for Progesterone Resistance

Step Down FSH Approach and Late Follicular Phase in Progesterone Level

FSH
Start date: November 23, 2017
Phase: Early Phase 1
Study type: Interventional

Step-down approach and late follicular phase progesterone level