Procedural Sedation Clinical Trial
Official title:
Procedural Sedation for Painful Orthopedic Manipulations With Propofol vs. Midazolam/Ketamine in the Adult Emergency Department
The use of procedural sedation and analgesia (PSA) to accomplish painful procedures in the
emergency department (ED) has become a standard of practice over the last decade.
Substantial variance exists regarding usage of medication for PSA, and many anesthetic
agents have been proposed for this use.
To our knowledge no head to head study compared the clinical effectiveness, safety profile
and amnestic properties of midazolam/ketamine vs. propofol regimens for PSA in the adult ED
setting.
This prospective randomized trail can will help to evaluate the effectiveness and safety
profile of Midazolam/katamine regimen for ED PSA in adults and will contribute to the
discussion regarding propofol roll in the ED.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03692390 -
Virtual Reality vs. Standard-of-Care for Comfort Before and After Sedation in the Emergency Department
|
N/A | |
| Completed |
NCT02145169 -
Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study
|
N/A | |
| Recruiting |
NCT05595798 -
EEG Spectral Pattern of Deep Sedation-induced Airway Adverse Effects
|
||
| Completed |
NCT01260662 -
Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
|
Phase 4 | |
| Completed |
NCT00327392 -
A Safety Study of AQUAVAN® (Fospropofol Disodium) Injection for Sedation During Minor Surgical Procedures.
|
Phase 2/Phase 3 | |
| Recruiting |
NCT04873596 -
Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia
|
Phase 2 | |
| Completed |
NCT03329014 -
A Trial of Intranasal Remimazolam Pharmacokinetics, Pharmacodynamics, Safety and Bioavailability
|
Phase 1 | |
| Recruiting |
NCT03860831 -
Intranasal Ketamine and Midazolam Mixture for Procedural Sedation in Children With Mental Disabilities:
|
Phase 1 | |
| Completed |
NCT00869440 -
Dose-Finding Safety Study Evaluating Remimazolam (CNS 7056) in Patients Undergoing Diagnostic Upper GI Endoscopy
|
Phase 2 | |
| Not yet recruiting |
NCT05757622 -
Electroencephalogram Based Real-Time Sedation Level Prediction
|
||
| Completed |
NCT03799783 -
The Use of Dexmedetomidine for EEG Sedation in Children With Behavioural Disorders
|
Phase 2 | |
| Completed |
NCT02180737 -
Dexmedetomidine for Sedation During Radiological Interventional Procedures
|
Phase 4 | |
| Not yet recruiting |
NCT01227174 -
Safety and Efficacy of Propofol Only Sedation in Oral and Maxillofacial Surgery
|
Phase 4 | |
| Recruiting |
NCT03499886 -
Low-Dose Intravenous Ketamine Bolus Versus Conventional Technique
|
Phase 2/Phase 3 | |
| Completed |
NCT03747432 -
Comparison of Procedural Sedation With Propofol and Dexmedetomidine During Transcatheter Aortic Valve Implantation
|
Phase 4 | |
| Recruiting |
NCT06203522 -
Factors Associated With Successful Completion of MRI in Children Undergoing a Vigil Sedation With Dexmedetomidin
|
||
| Withdrawn |
NCT05783492 -
INK Feasibility Study
|
Phase 3 | |
| Recruiting |
NCT04686448 -
Ketofol Versus Fenofol as Procedural Sedation for Carpal Tunnel Release
|
Phase 1/Phase 2 | |
| Completed |
NCT02955732 -
Pharmacological Characteristics of Intranasally Given Dexmedetomidine in Paediatric Patients
|
Phase 4 | |
| Recruiting |
NCT04746079 -
Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine
|
N/A |