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A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis — PSC  

Primary Sclerosing Cholangitis Clinical Trial

Official title:
A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis

Clinical Trial Summary

The purpose of this study is to determine whether Vancomycin or Metronidazole is safe and beneficial in the treatment of Primary Sclerosing Cholangitis.

Clinical Trial Description

In this protocol, we propose the assessment of potential beneficial effects of the antibiotics vancomycin and metronidazole on liver biochemistries, liver related symptoms and Mayo risk score in patients with PSC. The patients will be randomized into four groups of ten patients: one group will receive low dose vancomycin, one group will receive high dose vancomycin, one group will receive low dose metronidazole and one group will receive high dose metronidazole. Each group will be treated for three months. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01085760
Study type Interventional
Source Mayo Clinic
Contact
Status Completed
Phase Phase 1
Start date February 2010
Completion date November 2011
View Details
See also
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