Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT03313011 |
Other study ID # |
17-002468 |
Secondary ID |
|
Status |
Recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
August 1, 2017 |
Est. completion date |
July 2027 |
Study information
Verified date |
April 2024 |
Source |
Mayo Clinic |
Contact |
Sarah M Boland, CCRP |
Phone |
507-284-3863 |
Email |
boland.sarah[@]mayo.edu |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
The purpose of this study is to identify and distinguish two different types of Progressive
Apraxia of Speech through clinical imaging and testing.
Description:
Apraxia of speech (AOS) is a motor speech disorder reflecting a problem with the programming
and/or planning of speech. AOS is well recognized in the context of stroke where onset is
acute and the condition improves or is stable and chronic. AOS that is insidious in onset and
progresses over time because of neurodegeneration is less well recognized and understood. For
the past decade the investigators have been studying patients with primary progressive
apraxia of speech (PAOS). They have demonstrated that it can be the earliest manifestation of
an underlying neurodegenerative disease and have recently reported that the profile of PAOS
characteristics can differ among affected patients. In some instances, the speech pattern is
dominated by distorted sound substitutions and additions, and other features attributable to
articulatory difficulty, while in other instances the pattern is dominated by slow,
prosodically segmented speech. We have designated the first profile as Phonetic PAOS
(Ph-PAOS) and the second as Prosodic PAOS (Pr-PAOS; previously referred to in our studies as
type 1 and 2, respectively). Importantly, it appears that the AOS pattern type may have
prognostic implications. In a recent longitudinal study, the investigators observed that in
some PAOS patients, the AOS remained the most salient feature over an average of seven years
of the neurodegenerative disease. Other patients developed a severe extrapyramidal syndrome,
resembling progressive supranuclear palsy, within five years, causing significant morbidity,
including the inability to ambulate and a shortened life span; interestingly, this more
aggressive course was associated with the Pr- PAOS type. At present, little is known about
these types. To address the main aim to better understand the neurobiology and clinical
associations of PAOS types, they will perform longitudinal speech, language, and
neurocognitive testing, acoustic analyses, neuroimaging, and autopsy in a cohort of 47 new
PAOS patients (for 80 PAOS patients total) and healthy controls.