Primary Open Angle Glaucoma Clinical Trial
— HFDSOfficial title:
Microinvasive Glaucoma Surgery -The Lowering Effect of Intraocular Pressure on Glaucoma Patients With High Frequency Deep Sclerotomy
NCT number | NCT05466526 |
Other study ID # | 111-042-F |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | July 1, 2022 |
Est. completion date | June 30, 2023 |
Highlights the high-frequency deep sclerotomy (HFDS) as a promising ab-interno surgery in primary open-angle glaucoma (POAG) patients and evaluates the efficacy and safety of the procedure.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | June 30, 2023 |
Est. primary completion date | June 30, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 80 Years |
Eligibility | Inclusion Criteria: - Patients with chronic open angle glaucoma and were indicated for surgery due to either progression of field defect and raised intraocular pressure above 21 mmHg in spite of maximum medical treatment or for patients who were not compliant patient to their medical treatment. Exclusion Criteria: - Patients with close-angle, congenital, traumatic, neovascular, and uveitic glaucoma, patients with prior penetrating and nonpenetrating glaucoma surgeries or laser therapy, and eyes with corneal opacity precluding visualization of the angle. |
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital Hsin-Chu Branch | Hsinchu |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital Hsin-Chu Branch | Local clinic |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change of intraocular pressure (IOP) after HFDS treatments compared to preoperative IOP. | The postoperative IOP will be measured in every follow-up visit for 6 months after the operation. If the IOP of the participants is lower than that before the operation, and there is no tendency to increase within six months as well as no additional complications occur, the benefits of the primary outcome will be achieved. | Postoperative day 1, day 7, day 14, 1st month, 2nd month, 3rd months, 4th month, 5th month and 6th months. | |
Secondary | Change of visual acuity (VA) after HFDS treatments compared to preoperative VA. | The postoperative visual acuity(VA) will be measured in every follow-up visit for 6 months after the operation. If the VA of the participants is getting better than that before the operation, and there is no tendency to worse within six months as well as no additional complications occur, the benefits of the secondary outcome will be achieved. | Postoperative day 1, day 7, day 14, 1st month, 2nd month, 3rd months, 4th month, 5th month and 6th months. |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05564091 -
Cataract Surgery in Conjunction With Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients With Mild to Moderate Primary Open-Angle Glaucoma
|
N/A | |
Recruiting |
NCT02792803 -
A Comparison of Xalatan (Latanoprost) to Apo-latanoprost and Co-latanoprost in the Treatment of Glaucoma
|
Phase 4 | |
Terminated |
NCT02801617 -
Non-inferiority of PRO-067 Ophthalmic Solution vs GAAP Ofteno® in Glaucoma or Ocular Hypertension
|
Phase 3 | |
Completed |
NCT01384149 -
EXTERNAL SLT Treatment in Patients With Uncontrolled OPEN ANGLE GLAUCOMA
|
Phase 1 | |
Completed |
NCT00300079 -
Study of the Intraocular Pressure (IOP)-Lowering Efficacy of Azopt 1.0% Compared to Timolol 0.5% in Patients With Glaucoma or Ocular Hypertension
|
Phase 4 | |
Enrolling by invitation |
NCT00221923 -
African Descent and Glaucoma Evaluation Study
|
||
Recruiting |
NCT05605743 -
Alternate Nostril Breathing Training in Geriatrics With Glaucoma and High Blood Pressure
|
N/A | |
Completed |
NCT04828057 -
Preservative-free Fixed-dose Combination of Tafluprost 0.0015% / Timolol 0.5% in Patients With Open-angle Glaucoma or Ocular Hypertension: Clinical Effectiveness, Tolerability and Safety in a Real World Setting
|
||
Completed |
NCT01442896 -
STudy to Assess Rapid Disease Progression by Clinical and Genetic Factors In Glaucoma patientS That Are High Risk
|
||
Enrolling by invitation |
NCT05557721 -
Uddevalla Skövde Transscleral Micropulse Study
|
||
Recruiting |
NCT04595227 -
Glaucoma Screening Using Dynamic Analysis of Computerized Pupillary Light Reflex Assessment Device
|
||
Terminated |
NCT04141865 -
Effect of Xen Implantation on the Aqueous Humor Proteome
|
||
Completed |
NCT01943721 -
A Study of the VISION5 Product in Patients With Glaucoma or Ocular Hypertension
|
Phase 1 | |
Completed |
NCT01979913 -
An Open, Non-randomized Pilot Study on the Effect of Preservative Free Tafluprost (Saflutan® Augentropfen) in Patients With Ocular Hypertension or Primary Open Angle Glaucoma With an Uncontrolled Intraocular Pressure of 30 mmHg and More
|
Phase 4 | |
Not yet recruiting |
NCT01711177 -
Effect of Travoprost 0.004% on Retinal Oximetry in Primary Open Angle Glaucoma
|
N/A | |
Completed |
NCT02023242 -
Comparing Effectiveness of the Hydrus Microstent (TM) to Two iStents to Lower IOP in Phakic Eyes
|
N/A | |
Completed |
NCT01769521 -
Relationship Between 24-hour IOP Pattern and the 24-hour Blood Pressure Pattern in Patients With POAG
|
N/A | |
Recruiting |
NCT00773123 -
Efficacy of Retinal Nerve Fiber Layer (RNFL) / Ganglion Cell Layer Thickness Ratio by RT-View Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma.
|
N/A | |
Recruiting |
NCT00773877 -
Comparison of Retinal Nerve Fiber Layer (RNFL) Thickness Measurements by Time-Domain and Spectral-Domain OCT In Glaucoma Patients
|
N/A | |
Completed |
NCT02544646 -
Changes in Ocular Rigidity After Trabeculectomy in Patients With POAG
|
N/A |