Correlation of Optic Disk Morphology and Ocular Perfusion Parameters in Patients With Primary Open Angle Glaucoma

Primary Open Angle Glaucoma Clinical Trial

Official title:

Correlation of Optic Disk Morphology and Ocular Perfusion Parameters in Patients With Primary Open Angle Glaucoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00803504
• Other study ID #: OPHT-120905
• Status: Completed
• Phase: N/A
• First received: December 3, 2008
• Last updated: December 4, 2008
• Start date: November 2006
• Est. completion date: August 2007

Study information

• Verified date: December 2008
• Source: Medical University of Vienna
• Contact: n/a
• Is FDA regulated: No
• Health authority: Austria: Agency for Health and Food Safety
• Study type: Observational

Clinical Trial Summary

Glaucoma is one of the most common causes of blindness in the industrialized nations. For a long time glaucoma has been defined as a disease in which high intraocular pressure (IOP) leads to irreversible optic disc damage and subsequent visual field loss. However, recent investigations show that IOP is not the only factor that is involved in the glaucomatous process leading to retinal ganglion cell death. The role of vascular factors in the pathogenesis of glaucoma has recently received much attention based on animal experiments and epidemiological studies. It is, however, assumed that vascular factors do not contribute to same degree in all glaucoma patients. Generally, it is believed that a vascular component is more important in normal tension glaucoma patients and patients with underlying cardiovascular disease. Little is, however, known about a potential association between optic nerve head morphology and ocular perfusion in POAG patients. The current study seeks to gain insight into this association by assessing ocular blood flow parameters with a number of noninvasive technologies.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 103
• Est. completion date: August 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Men and women over 18 years

• Unilateral or bilateral primary open angle glaucoma

• At least 3 reliable visual field tests showing CPSD >= 2.0 in the eye that will be studied

Exclusion Criteria:

• History of acute angle closure

• Closed or barely open anterior chamber angle

• Standard deviation of visual field testing > 10

• Intraocular surgery or argon laser trabeculoplasty within the last six months

• Ocular inflammation or infection within the last three months

• Topical or systemically/oral therapy with steroids

Study Design

N/A

Related Conditions & MeSH terms

• Glaucoma
• Glaucoma, Open-Angle
• Primary Open Angle Glaucoma

Intervention

Procedure:
• ocular blood flow measurement

Locations

Country	Name	City	State
Austria	Deparmtent of Clinical Pharmacology	Vienna

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Optic nerve head blood flow (scanning laser Doppler flowmetry, laser Doppler flowmetry)			No
Primary	Retinal blood flow (scanning laser Doppler flowmetry, laser Doppler velocimetry + retinal vessel analyzer)			No
Primary	Choroidal blood flow (laser Doppler flowmetry, laser interferometry, pneumotonometry)			No
Primary	Optic nerve head morphology parameters			No
Primary	Fundus photography: evaluation based on Jonas et al. 2003 J Glaucoma 12:260-265,			No
Primary	Heidelberg Retina Tomograph: evaluation based on Iester et al. 2001 Am J Ophthalmol 132: 57-62,			No