How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?

Primary Open Angle Glaucoma Clinical Trial

Official title:

Nuclear Genetic and Mitochondrial Influences in Glaucoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00626847
• Other study ID #: IRB#07-826
• Status: Completed
• Phase: N/A
• First received: February 20, 2008
• Last updated: November 17, 2016
• Start date: March 2008
• Est. completion date: August 2009

Study information

• Verified date: November 2016
• Source: Wills Eye
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.

Description:

Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 97
• Est. completion date: August 2009
• Est. primary completion date: August 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 40 Years and older

Eligibility

Inclusion Criteria:

• 40 yrs

• Caucasian or African American

• Male or female with POAG, PACG, PXFG,

• Normal

Exclusion Criteria:

• Other ophthamic co-morbidities

• Other ethnic groups

• Unable to understand and give informed consent

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Glaucoma
• Glaucoma, Open-Angle
• Primary Open Angle Glaucoma

Locations

Country	Name	City	State
United States	Wills Eye Glaucoma Service	Philadelphia	Pennsylvania

Sponsors (3)

Lead Sponsor	Collaborator
Wills Eye	Jefferson Medical College of Thomas Jefferson University, Thomas Jefferson University

Country where clinical trial is conducted

United States, 

References & Publications (2)

Abu-Amero KK, Azad TA, Spaeth GL, Myers J, Katz LJ, Moster M, Bosley TM. Absence of altered expression of optineurin in primary open angle glaucoma patients. Mol Vis. 2012;18:1421-7. — View Citation

Abu-Amero KK, Azad TA, Spaeth GL, Myers J, Katz LJ, Moster M, Bosley TM. Unaltered myocilin expression in the blood of primary open angle glaucoma patients. Mol Vis. 2012;18:1004-9. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma.		one blood draw	No