Primary Immune Deficiencies Clinical Trial
Official title:
Study of Gut Microbiota in Primary Immune Deficiencies, Possibly Associated With Inflammatory Bowel Disease (Chronic Granulomatous Disease, XIAP Gene Deficiency, or TTC7A Gene Deficiency)
Some Primary Immune Deficiencies can be associated with an inflammatory bowel disease,
mimicking Crohn disease : the Chronic Granulomatous Disease (CGD), the XIAP deficiency, and
the TTC7A deficiency.
This inflammatory bowel disease is frequent but inconstant, raising questions about other
factors contributing to the disease. The aim of our study is to analyze, describe and compare
the gut microbiota of patients with those primary immune deficiency, with or without
intestinal disease.
The investigators can expect, in the long term, to compare on a same patient, the gut
microbiota evolution, and to assess the role of gut microbiota modifications on the onset of
an inflammatory bowel disease.
The investigators will include patients (adults or children), with Primary Immune Deficiency
(CGD, XIAP or TTC7A deficiencies), and they will collect feces samples from them.
In parallel, as control groups, patients with no inflammatory bowel disease and no primary
immune deficiency will be included, and also patients suffering from Crohn's disease without
known primary immune deficiency.
The laboratory collaborators will then realize analyzes on the microbiota collected for all
patients.
The study team will then analyze the microbiota composition of the different types of
patients, and try to identify some factors, associated with the appearance of an inflammatory
disease on these patients.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT01222741 -
Studies of Disorders With Increased Susceptibility to Fungal Infections
|
||
| Active, not recruiting |
NCT01981785 -
Investigation of Immune Disorders and Deficiencies
|
N/A |