Clinical Trials Logo
  1. Home
  2. Primary Hypertension
  3. NCT03015311

Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients — STEP  

Primary Hypertension Clinical Trial

Official title:
Strategy of Systolic Blood Pressure Intervention in the Elderly Hypertensive Patients: A Prospective Randomized Open-Label Blinded-Endpoint Trial

Clinical Trial Summary

The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) is a 2-arm, multi-center, prospective, randomized, open-labeled, blinded-endpoint trial. The purpose of this trial is to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal (<130 mmHg, intensive treatment) than currently recommended (<150 mmHg, standard treatment) will reduce CVD risk among persons between 60-80 years of old. Furthermore, this trial will also examine the effect of blood pressure APP management strategy via WeChat network on medication compliance, blood pressure control and CVD benefits.

Clinical Trial Description

Hypertension is highly prevalent in the adult population in China, and its burden is rapidly increasing among persons older than 60 years of age. Elevated blood pressure (BP) is an important public health concern which contributes to several adverse health outcomes, especially coronary heart disease, stroke, heart failure, chronic kidney disease, and decline in cognitive function. Clinical trials have shown that a lower systolic blood pressure goal will lead to greater reduction in cardiovascular disease (CVD) incidence, but the effect of intensive treatment of systolic blood pressure below 120 mm Hg in reducing of CVD risk has long been debated. In particularly, among the elderly hypertensive patients aged 60 years or older, the most appropriate targets for blood pressure lowering to reduce cardiovascular events still remain uncertain. The STEP trial will randomize about 8000 participants aged between 60 and 80 years with SBP≥140 mm Hg and <190 mm Hg, and without a history of atherothrombotic or hemorrhagic stroke. Target SBP goals are 110-130 vs 130-150 mm Hg, respectively. The purpose of the STEP trial is to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal (<130 mmHg, intensive treatment) than currently recommended (<150 mmHg, standard treatment) will reduce CVD risk among hypertensive patients between 60-80 years. Participants will be recruited at approximately 40 clinic centers in China within approximately a 1-year period, and will be followed for 4 years. Furthermore, this trial will also examine the effect of blood pressure APP management strategy via WeChat network on medication compliance, blood pressure control and CVD benefits. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03015311
Study type Interventional
Source Chinese Academy of Medical Sciences, Fuwai Hospital
Contact
Status Active, not recruiting
Phase N/A
Start date January 15, 2017
Completion date December 31, 2021
View Details
See also
  Status Clinical Trial Phase
Completed NCT00573742 - Efficacy Observational Study of Candesartan Cilexetil on Hypertensive Patients N/A
Recruiting NCT06208072 - The Predictive Role of Urinary Proteomics in Blood Pressure Response of Obese Hypertensive Treated With Irbesartan or Eplerenone. N/A
Recruiting NCT06049862 - The Effectiveness of "MaRiTensi" in Increasing Self-Care and Blood Pressure Control: Randomized Controlled Trial N/A
Completed NCT00819104 - A Study to Compare the Efficacy, Safety and Tolerability of Selomax With Its Individual Components Phase 4
Not yet recruiting NCT06091176 - Assessment of Efficacy and Safety of Amicomed®, for the Management of Essential Hypertension N/A
Recruiting NCT01742702 - HaemoDYNAMICs in Primary and Secondary Hypertension
Recruiting NCT02817204 - Effect of Aerobic EXercise on MiCroVAscular RarefacTION in Chinese Mild HyperteNsive Patients（EXCAVATION-CHN1） Phase 3
Completed NCT00794885 - China Stroke Primary Prevention Trial Phase 4
Active, not recruiting NCT04381520 - Heat-sensitive Moxibustion Self-administration in Patients in the Community With Primary Hypertension: Protocol for a Multi-center, Pragmatic, Non-randomized Trial N/A
Completed NCT00865501 - Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease Phase 3
Active, not recruiting NCT04788563 - A Randomized Patient Preference Trial on Heat-sensitive Moxibustion for Primary Hypertension in Community N/A
Completed NCT02184858 - Dose Titration of Lisinopril in Children Aged 1 to 18 Years With Primary or Secondary Hypertension Phase 4
Completed NCT03105687 - Effectiveness of SMS Reminders of Blood Pressure-lowering Drugs Intake N/A
Completed NCT01392534 - Effects of Telmisartan/Hydrochlorothiazide Treatment in Hypertensive Patients Under Real-life Setting N/A
Enrolling by invitation NCT03470974 - The Effect of Self-Titration and Predictors for Blood Pressure Control in Patients With Hypertension N/A
Active, not recruiting NCT01844570 - Levamlodipine Maleate or Amlodipine Besylate for Treatment of Hypertension: A Comparative Effectiveness Research N/A
Completed NCT01241487 - A National Multicentre Study to Assess the Efficacy of the Fixed Combination of Valsartan and Amlodipine in Hypertensive Patients Not Controlled by Monotherapy Phase 4
Completed NCT00882947 - Post-Marketing Surveillance of Ventavis® in Chinese Patients With Primary Pulmonary Hypertension (PPH) Phase 4
Active, not recruiting NCT03310684 - Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
Not yet recruiting NCT02901704 - Renal Denervation by Iberis MultiElectrode Renal Denervation System in Patients With Primary Hypertension Phase 3