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Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience

Primary Graft Dysfunction Clinical Trial

Official title:
Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience

Clinical Trial Summary

Among the complications of heart transplant, primary dysfunction of the graft (PDG) is the most feared with a net impact on early morbidity and mortality. The all-cause mortality rate at the international level is 10% at 30 days and 34% at one year. Mortality at 30 days is secondary in 66% of cases with DPG or multi-organ failure.

The treatment of choice for the more severe PDG remains ECMO-type circulatory mechanical assistance or ventricular assistance. According to several studies, this could reduce early mortality. Early placement and short-term (<30 days) of support appear to improve survival in the first year after transplantation.

The haemodynamic parameters revealing this DPG are not clearly described in the literature.

hypothesis of this research is that:

- DPG risk factors in strasbourg's hospital center are comparable to other European and international centers.

- Simple hemodynamic parameters can be used to detect PDG earlier in order to set up assistance more quickly.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03156894
Study type Observational
Source University Hospital, Strasbourg, France
Contact Gharib AJOB, MD
Phone 33 3 69 54 97 58
Email gharib.ajob@chru-strasbourg.fr
Status Recruiting
Phase N/A
Start date January 1, 2017
Completion date March 1, 2018
View Details
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