Clinical Trials Logo

Clinical Trial Summary

Tocolytic agents are used for the treatment of preterm labor. It is unclear whether combination treatments of two tocolytic agents are more effective in stopping preterm labor compared to one. Therefore, the investigators propose a comparative effective trial of nifedipine plus indomethacin vs. nifedipine alone for the treatment of preterm labor


Clinical Trial Description

The investigators current treatment for preterm labor has not been shown to be effective in prolonging pregnancy sufficiently to improve neonatal outcomes and other treatment strategies are needed. Multiple examples demonstrate that multi-agent treatments are routine clinical practice in other fields of medicine including chemotherapeutics for cancer, multi-therapeutics for myocardial infarction and broad spectrum antibiotics for pneumonia. At this time, it is unclear if a combination of tocolytic medications for preterm labor is more advantageous for women. If pregnancy is prolonged with combined tocolytic therapy, this could directly influence the treatment of preterm labor and potentially improve neonatal outcomes. There currently are no trials of combination regimens using widely used tocolytic agents, such as nifedipine and indomethacin. Thus, we propose a comparative effective trial of nifedipine plus indomethacin vs. nifedipine alone for the treatment of preterm labor ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02438371
Study type Interventional
Source The University of Texas Health Science Center, Houston
Contact
Status Terminated
Phase Phase 4
Start date May 2015
Completion date October 10, 2019

See also
  Status Clinical Trial Phase
Active, not recruiting NCT06168149 - The Relationship of Fetal Lung Elastography Values With the Development of Respiratory Distress in Cases of Preterm Labor
Completed NCT02538718 - Efficacy and Safety of MgSO4 as Tocolytics Compared to Ritodrine in Preterm Labor N/A
Not yet recruiting NCT05864066 - Cyclin-dependent Kinase Inhibitor 2A (Placental Senescence Marker) on Labor-related Signals
Terminated NCT03715530 - Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women N/A
Recruiting NCT03638037 - Correlation Between Maternal Vitamin D Level And Preterm Birth
Recruiting NCT03992534 - The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth Phase 1
Completed NCT02536352 - Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being Early Phase 1
Withdrawn NCT03122704 - Group B Streptococcus (GBS) Infection and in Preterm Labor Women Conceived Through IVF N/A
Recruiting NCT01518816 - Role of Serum Total Antioxidant Level in Preterm Labor N/A
Recruiting NCT04590677 - Prediction of the Onset of Term and Preterm Labour
Completed NCT03112018 - Strengthening Facility-based Intrapartum/Immediate Newborn Care to Reduce Mortality of Preterm Infants in Migori County, Kenya and Busoga Region, Uganda N/A
Active, not recruiting NCT04301518 - Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs N/A
Completed NCT03785795 - Multichannel EMG Diagnosing True Preterm Labor
Withdrawn NCT02351310 - Effectiveness of ACS in Extreme Preemies Phase 3
Not yet recruiting NCT01985594 - Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial Phase 2
Not yet recruiting NCT04532086 - Uterocervical Angle and Preterm Labour
Completed NCT04605172 - Lockdown Impact on Spontaneous Premature Birth in a Level III NICU
Recruiting NCT04417595 - Investigating N-3 Fatty Acids to Prevent Neonatal Tobacco-related outcomeS Phase 2
Completed NCT03923023 - Impact of the PREEMI Package on Neonatal Mortality
Recruiting NCT06157203 - Labor Status Monitor for Diagnosing True vs False Labor in Preterm Patients