Preterm Birth Clinical Trial
Official title:
Relationship Between Fetal Right Heart Doppler Findings With Lamellar Body and Fetal Lung Maturity
Objective: The aim of this study was to investigate the efficacy of fetal right heart doppler
findings in determination of pulmonary maturity.
Materials and Methods: Pregnant women refered to the Department of Obstetrics and Gynecology
at Karadeniz Technical University were included in the study. Pregnant women with
pregestational or gestational diabetes mellitus, morbid obesity, thyroid dysfunction and
fetal abnormality aneuploidy were not included in the study. The study was planned on women
with late preterm and term pregnancy. Late preterm cases between 34-37 weeks were included in
study group and term cases over 37 weeks were in control group. The doppler findings of main
pulmonary artery and right pulmonary artery, mitral valve e/a wave ratio and lamellar body
count were determined as the main outcomes. During caesarean section, 5cc amniotic fluid was
taken to measure lamellar bodies count. Perinatal results of patients were recorded. p<0.05
was considered as statistical significance.
MATERIAL AND METHODS This study is a prospective clinical study and it was initiated after
the approval of Karadeniz Technical University Faculty of Medicine Clinical Research Ethics
Committee numbered 2017/88.
Between 2017-2019 years, pregnant women included in the study who admitted to the Department
of Obstetrics and Gynecology at Karadeniz Technical University. The study was planned on
cases who will undergo cesarean section over 34. week of gestation. They were not included in
the study if pregnant women with pregestational or gestational diabetes mellitus, morbid
obesity, thyroid dysfunction and fetal anomaly diagnosed aneuploidy or anomaly. Demographic
data, ultrasonographic data and doppler parameters of all patients were recorded and
evaluated prospectively. Informed consent was obtained from all participants prior to
participation to work. Newborn results after birth were recorded.
Patients were divided into two groups. The study group consisted of late preterm cases (34-37
weeks of gestation) and the control group consisted of term cases (<37 weeks of gestation).
Doppler data of main pulmonary artery and right pulmonary artery, mitral valve e/a wave ratio
and lamellar body count were determined as the main research parameters. In both groups,
fetal thorax and heart circumference ratio, mitral e/a wave ratio, right pulmonary artery and
main pulmonary doppler indexes (PI, RI, S / D, AT / ET) were evaluated before cesarean
section. All ultrasonographic examinations and measurements were performed by a single
operator with color doppler ultrasonography device. Doppler measurements were performed in
supine and slightly left-facing position. Doppler index measurements of two groups were
recorded separately for each pregnant.
Lamellar Body Count Lamellar body counting; at least 2cc of amniotic fluid not infected with
blood during the cesarean section was taken into the EDTA tube and not centrifuged in
thestudy. The sample was studied by using automatic blood counting device which is used for
counting the shaped elements of blood called Coulter Counter which makes automatic blood
count in hematology laboratories. The value specified in the platelet count part was accepted
as the number of lamellar bodies in the report.
Statistical analysis All data were analyzed using with IBM SPSS Statistics 11 (IBM SPSS,
Turkey). In addition to descriptive statistical methods, Student's t test was used to compare
the quantitative data.
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