Preterm Birth Clinical Trial
Official title:
Effect of Early Use of Caffeine Citrate in Preterm Neonates Needing Respiratory Support.
This work is designed to study the effect of the early use of caffeine citrate in preterm neonates who need respiratory support on morbidity and short term neonatal outcome.
Caffeine citrate is one of the most widely used drugs in neonatal intensive care units. It is
a respiratory stimulant which has well established therapeutic effects in apnea and
facilitation of extubation. Caffeine is an adenosine antagonist ; it blocks selectively A2
receptors and non selective blocks A1 receptors. Its effects include improved lung
compliance, minute ventilation, respiratory muscle contractility, increased sensitivity to
carbon dioxide, enhanced catecholamine activity and decreased airway resistance
Early caffeine therapy was associated with a shorter duration of respiratory support and
reduction in bronchopulmonary dysplasia , cerebral palsy, patent ductus arteriosis ligation,
intracranial hemorrhage, apnea and death
Despite its widespread use, information regarding optimal time to initiate therapy and
appropriate time to discontinue therapy is limited. Recent studies have indicated that early
initiation of caffeine therapy is associated with improved neonatal outcomes
Little is known about the early use of caffeine citrate in preterm neonates. The
investigators aim to explore the effectiveness of its very early use in reducing the duration
of respiratory support.
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