Preterm Birth Clinical Trial
Official title:
What is the Impact of Early Life Exposures on the Cardiovascular System in Young Adulthood? A 25-Year Follow-up Study of Preterm-born Individuals
The purpose of this study is to investigate whether early life exposures such as premature birth or exposure to preeclampsia before you are born results in long-term alterations in the cardiovascular system that increase risk of cardiovascular disease development.
While the incidence of cardiovascular disease has reduced dramatically, coinciding with
favourable changes in risk factors, cardiovascular disease remains the single largest cause
of mortality and premature mortality in the United Kingdom. Identification of novel
biological pathways that underlie disease susceptibility raises the potential for new early
primary prevention strategies to complement classical management. There is particular
interest in the role of early environment in 'programming' risk of cardiovascular disease in
later life and growing evidence that various early life exposures impact cardiovascular
health in the longer term.
We have thus designed the Early Vascular Study to investigate the long-term impact of early
life exposures, with a particular focus on the impact of preterm birth, in the presence or
absence of pregnancy-induced hypertension in the mother, on the cardiovascular system in
young adulthood. This study also allows investigation of the long term impact of perinatal
interventions used in this cohort. Comprehensive multi-modality non-invasive imaging measures
of cardiovascular structure and function allow precise quantification of cardiovascular
phenotype. This is combined with blood sample collection to study changes in molecular and
metabolic markers and pathways.
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