Effectiveness of Guided Imagery Intervention on Factors Associated With Maternal Stress and Preterm Birth

Preterm Birth Clinical Trial

Official title:

Guided Imagery Effects on Pregnancy Symptoms and Outcomes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01436786
• Other study ID #: 12900
• Secondary ID: 5P30NR011403
• Status: Completed
• Phase: N/A
• First received: September 6, 2011
• Last updated: May 14, 2014
• Start date: June 2010
• Est. completion date: August 2012

Study information

• Verified date: May 2014
• Source: Virginia Commonwealth University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Demonstrating the effectiveness of an economical and feasible intervention such as guided imagery on factors associated with preterm birth, along with better understanding of pathways leading to adverse birth outcomes has tremendous health, social, and financial benefits. This project has the potential to significantly advance the field of nursing and knowledge development in the areas of maternal stress reduction in African American women and to provide scientific evidence of the effectiveness of guided imagery.

Description:

Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality and has tremendous health and economic costs for the infant, family, and society. There has been little success in reducing PTB; rates are at an all time high. Of particular concern is the major racial disparity in PTB rates; African American women have the highest proportion of PTB compared to women of other races or ethnicities. There is growing evidence suggesting that PTB may be the end point of sub-acute or chronic pathophysiological changes that occur before clinical symptoms of preterm labor are present. There is also evidence to suggest that psychosocial factors such as maternal stress and the related symptoms of fatigue, anxiety, depression, as well as unhappiness about the pregnancy are associated with negative birth outcomes. It is proposed that these behavioral factors could influence birth outcomes through two possible pathways: (1) a neuroendocrine pathway in which maternal stress may lead to early and/or greater activation of the maternal-placental-fetal endocrine systems, with CRH playing a key role, thereby promoting labor; and/or (2) immunologic or inflammatory pathways which may promote labor through pro-inflammatory mechanisms. Experts agree primary prevention interventions are needed to address the issue of PTB. Guided imagery (GI) has been effective in decreasing self-reported measures of stress, depression, and fatigue as well as influencing neuroendocrine and immune measures in the general population. However, there are only limited studies examining the effects of GI on maternal stress, neuroendocrine measures, and/or birth outcomes, and there are no published studies examining the effect of GI as a primary prevention intervention to improve birth outcomes by reducing stress and related symptoms and influencing the proposed immunologic pathway to PTB. The specific aims of this randomized clinical trial are (1) to test the effects of a GI intervention on maternal stress (perceived stress), related symptoms (fatigue, anxiety, depression, and unhappiness), neuroendocrine (CRH) and immunological mediators (IL-1β, IL-6, Il-8, IL-10, IL-12, TNF-α, IFN-γ, G-CSF, GM-CSF), and birth outcomes (gestational age and neonatal birthweight) in African American women; and (2) to test the proposed theoretical model by examining predicted relationships among stress, fatigue, anxiety, depression, unhappiness, patterns of neuroendocrine and immunologic factors, and birth outcomes. An analysis of covariance (ANCOVA) model will be used to test for group differences between the GI and control groups. To test the proposed theoretical model descriptive statistics, graphical methods and pairwise correlations will be calculated for all baseline data and canonical correlation analysis will be used to look for relationship among groups of the baseline variables. Demonstrating the effectiveness of an economical, easy to distribute and use, intervention on the psychosocial factors associated with PTB and the proposed pathways leading to adverse birth outcomes has tremendous health, social and financial benefits. This project will provide baseline data for further research to test the biobehavioral efficacy of this intervention in larger samples with multiple races/ethnicities as well as test the model during the postpartum period for maternal well-being and infant development.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 73
• Est. completion date: August 2012
• Est. primary completion date: August 2012
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Being pregnant between 14-17 weeks gestation

• Being African American

• 18 years of age or older

• able to read, write and understand English

• verbalize a source of social support

• self-report of no change in level of stress management strategies used within the last month.

Exclusion Criteria:

• carrying multiples

• have had cervical cerclage

• currently use oral corticosteroids

• have uterine or cervical abnormality

• have dissociative disorders, borderline personalities or psychotic pathology

• have medical and/or pregnancy complications known to impact cytokine levels (e.g., gestational diabetes)

• currently use GI techniques.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Screening

Related Conditions & MeSH terms

• Maternal Stress
• Premature Birth
• Preterm Birth

Intervention

Other:
• Guided Imagery
The 12 week intervention consists of a set of 4 GI compact discs (CDs), each 20 minutes in length. Participants will be instructed to listen to the CD once a day in a recommended order for weeks 1-4 and used in any order for weeks 5-12.

Locations

Country	Name	City	State
United States	Virginia Commonwealth University	Richmond	Virginia

Sponsors (2)

Lead Sponsor	Collaborator
Virginia Commonwealth University	National Institute of Nursing Research (NINR)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	maternal stress (perceived stress)		baseline	No
Primary	maternal stress (perceived stress)		8th Week	No
Primary	maternal stress (perceived stress)		12th Week	No
Secondary	neuroendocrine (CRH) and immunological mediators (IL-1ß, IL-6, Il-8, IL-10, IL-12, TNF-a, IFN-?, G-CSF, GM-CSF)		baseline	No
Secondary	neuroendocrine (CRH) and immunological mediators (IL-1ß, IL-6, Il-8, IL-10, IL-12, TNF-a, IFN-?, G-CSF, GM-CSF)		8th Week	No
Secondary	neuroendocrine (CRH) and immunological mediators (IL-1ß, IL-6, Il-8, IL-10, IL-12, TNF-a, IFN-?, G-CSF, GM-CSF)		12th Week	No