Prematurity of Fetus Clinical Trial
Official title:
Investigations on Improving Docosahexaenoic and Arachidonic Acid Content in Preterm Infant Formula
The investigators examined the effect of different levels of docosahexaenoic aicd (a long
chain polyunsaturated fatty acid) intake on the fatty acid composition of plasma and
erythrocyte phospholipids and on the maturity of visually evoked potentials in preterm
infants. As a secondary outcome the conversion of linoleic acid and alpha linolenic acid
into their corresponding long chain polyunsaturated fatty acids was studied.
Preterm infants were randomized in a double-blind fashion to one of three formulas
containing different amounts of docosahexaenoic acid during the first two weeks of postnatal
life. A control group received human milk. Blood samples were collected at study entry and
14 and 28 days thereafter. Uniformly 13C-labeled linoleic acid and alpha linolenic acid were
applied orally before blood sampling at day 28. At postconceptional ages 48 weeks and 56
weeks visually evoked potentials were recorded.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care
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