Premature Clinical Trial
Official title:
Impact of Prematurity on the Morphological and Tomographic Aspect of the Papilla
The purpose of this protocol is to study the consequences of prematurity on the optic nerve.
Indeed, the work already carried out on the subject suggests that prematurity induces
suffering of the optic nerve with a loss of optical fibre, an essential element in the
transmission of the visual nerve signal to the brain.
The investigators will therefore study two populations: a population of premature infants
aged 5 to 10 years, and a control population of term infants.
The examinations performed are painless, non-invasive and non-irradiating. To date, there are
no known adverse reactions to these tests. These examinations are a photo of the fundus
(retinophotography), a pachymetry (measurement of the thickness of the non-contact cornea),
an OCT RNFL (optical coherence tomography, scanner of the non-irradiating non-painful optical
nerve) and the taking of the IOP (intraocular pressure).
They aim to measure the main morphological characteristics of the eye and the optic nerve.
This is a prospective observational study. The inclusion and measurements necessary for the
study are made on the day of the consultation.
The expected results will provide new data on this population of premature infants, allowing
for better management if a pathology involving the optic nerve were to occur at any age in
these patients.
The prematurity of the newborn is now a major theme in medical research. Indeed,
technological progress makes it possible to revive increasingly premature children. But being
born premature also brings many complications, some of which are already well known
(pulmonary, cardiac, digestive complications, etc....). At the ophthalmological level, the
retinopathy of the premature child is an entity already well described, this retinal
vascularization anomaly leads to many complications on the child's visual future. The optic
nerves of premature infants are described as larger than those of normal children.
Recently, a new ophthalmological condition has been described. This is the damage to the
optic nerve of the premature baby, characterized by a loss of optical fibres, of major
importance in the transmission of the visual signal to the brain.
The aim of this study is to characterize the particularities of the optic nerve of the
premature child, as there is currently very little data available on it in this context. Some
studies have reported this, but with results that are not always homogeneous. For example,
some studies report a lack of optic fiber in the temporal area of the optic nerve, while
others find more pronounced atrophy on the nasal side, which has practical consequences in
the examination and monitoring of these children.
A better understanding of these disorders would make it possible to establish monitoring
protocols for these children born with nerve fibre deficiency, especially to prevent
subsequent fibre loss due to any pathology of ocular tone, the best known of which is
glaucoma.
The purpose of this prospective study is to compare the aspects of optic nerves in premature
infants compared to those of optic nerves in non-premature infants. This aspect changes with
age, with a progressive physiological decrease in the thickness of optic fiber within the
optic nerve over time. It is therefore essential to match the two age groups to exploit this
data.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05968586 -
Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants
|
N/A | |
Not yet recruiting |
NCT05706584 -
The Effect of Metaverse-Based Nursing Skills Laboratory
|
N/A | |
Not yet recruiting |
NCT05530733 -
Clinical Effects of Pacifier Use in Preterm During Orogastric Tube Feeding
|
N/A | |
Withdrawn |
NCT04561700 -
Nutritive Sucking Patterns in Premature Infants
|
N/A | |
Recruiting |
NCT01443273 -
Thrombophilic Risk Factors in Preterm and Infants Treated at Ha'Emek Medical Center Between the Years 1990 to 2010
|
||
Recruiting |
NCT04565210 -
Effects of Oriental Music on Preterm Infants
|
N/A | |
Not yet recruiting |
NCT06072625 -
Enteral Feeding of Premature Babies and Olive Oil Supplementation
|
N/A | |
Recruiting |
NCT04866342 -
Servo Controlled Oxygen Targeting (SCO2T) Study: Masimo vs. Nellcor
|
N/A | |
Enrolling by invitation |
NCT04168749 -
Efficacy and Safety of Industrially Prepared 3 Chamber Bag Parenteral Nutrition for Premature Infant
|
||
Recruiting |
NCT04458441 -
Can Warm Skin Disinfection Reduce the Pain Peripheral Central Catheter Application in Premature Babies?
|
N/A | |
Recruiting |
NCT05835817 -
Magnetoencephalography by Optical Pumping Magnetometer
|
N/A | |
Enrolling by invitation |
NCT03061968 -
Study of Applying Acupressure in Low-birth Weight Premature
|
N/A | |
Recruiting |
NCT06207071 -
Early DHA/ARA Supplementation in Growth-restricted Very Preterm Infants: A Randomized Clinical Trial
|
N/A | |
Not yet recruiting |
NCT05806684 -
Hyperbilirubinemia and Retinopathy of Prematurity in Preterm Infants: a Retrospective Study.
|
||
Recruiting |
NCT05380401 -
Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants
|
N/A | |
Completed |
NCT04298346 -
Neurological Fate, Prematurity and Genetic Susceptibility Factors
|
||
Active, not recruiting |
NCT05343403 -
Parental Participation on the Neonatal Ward - the neoPARTNER Study
|
||
Completed |
NCT04035564 -
Early Sodium Intake in Preterm Newborns
|
Phase 4 | |
Recruiting |
NCT04432636 -
Gut Bacteria and Brain of the Baby
|
N/A | |
Recruiting |
NCT05301309 -
Integrative Early Breastfeeding Support in NICU
|
N/A |