Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation

Pregnancy Clinical Trial

Official title:

Effect of Beetroot Juice Consumption on Endothelial Function and Tissue Oxygen Saturation in Pregnant

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03315806
• Other study ID #: 56732216.5.0000.5699
• Status: Completed
• Phase: N/A
• First received: October 16, 2017
• Last updated: November 1, 2017
• Start date: October 6, 2016
• Est. completion date: May 19, 2017

Study information

• Verified date: November 2017
• Source: Universidade Federal do Rio de Janeiro
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus. Beetroot juice (BJ) promotes improvement ins this parameters in no-pregnant individuals, however the beneficial effect did not avaliated in pregnant. The present study evaluated effects of BJ on macro and microvascular endothelial function in pregnant. Twelve pregnant were submitted to BJ and nitrate-depleted juice (PLA) interventions. Brachial flow-mediated dilation (FMD) and muscle oxygenation were measured 120 min after interventions. Urinary nitrate, nitrite were measured at baseline and 120 min after interventions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: May 19, 2017
• Est. primary completion date: February 14, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• gestation between 20 and 35 weeks;

• over 18 years

Exclusion Criteria:

• diabetes mellitus and gestational diabetes;

• hypertensive syndromes;

• HIV positive;

• liver or kidney disease;

• beetroot allergy;

• use of antioxidants and medicament that alter endothelial function;

• use of antibiotics up to 2 weeks before the visits and using.

Related Conditions & MeSH terms

• Pregnancy

Intervention

Other:
• Beetroot juice
140 mL of beetroot juice cointaning approximately 9 mmol of nitrate
• Placebo
140 mL of beetroot juice isent of nitrate

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Universidade Federal do Rio de Janeiro

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Macro endothelial function	Flow-mediated dilation (FMD)	Evaluated 120 minutes after the nutritional intervention
Primary	Micro endothelial function	Tissue oxygen saturation parameters	Evaluated 140 minutes after the nutritional intervention
Primary	Nitrate urinary		Evaluated 150 minutes after the nutritional intervention