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Lactobacillus Reuteri Feasibility Study on Probiotic Treatment and Perinatal Microbiome

Pregnancy Clinical Trial

Official title:
Lactobacillus Reuteri Feasibility Study on Probiotic Lozenges, Probiotic Chewing Gum and Probiotic Capsules and Perinatal Microbiome Seeding During Pregnancy

Clinical Trial Summary

Investigators want to investigate if the Lactobacillus Reuteri (probiotic bacteria) given to pregnant women can be found in different maternal compartments and in the first stool and oral swab collected immediately after birth of a newborn delivered by cesarean delivery. Investigators also want to explore if exposure to this Lactobacillus Reuteri alters the level of inflammation in different compartments of the mother and the infant.

Clinical Trial Description

The purpose of this project is to better understand the following issues:

1. How does bacteria transmit from the mother to the fetus and placenta during pregnancy and to the infant during the first 2-6 weeks after birth?

2. Does colonization of the pregnant mother and fetus/Child occur? How and when?

3. Can orally given probiotic bacteria be found in the newborn 2-6 weeks after birth, and if so where?

4. How is bacteria transported from the mother's intestinal lumen to the Child/fetus gut?

5. What impact has these bacteria on the level of inflammation in maternal and fetal compartments, especially that normally seen in the intestine of all newborns?

6. What impact has these bacteria in the bowel on a normal intestinal flora establishment? ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02693028
Study type Interventional
Source Sahlgrenska University Hospital, Sweden
Contact
Status Completed
Phase N/A
Start date November 2015
Completion date January 2018
View Details
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