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Endometrial Injury Versus Luteal Phase Support in Intrauterine Insemination Cycles

Pregnancy Clinical Trial

Official title:
Endometrial Injury Versus Luteal Phase Support in Intrauterine Insemination Cycles

Clinical Trial Summary

The investigators will try to assess the effect of endometrial injury preceding the intrauterine insemination cycle on the pregnancy rates compared to cycles with luteal phase support and the control group.

Clinical Trial Description

Group 1: Endometrial biopsy is performed on days 21-24 of the spontaneous menstrual cycle proceeding the intrauterine insemination (IUI) treatment cycle. Two small biopsies are obtained from anterior and posterior walls of the uterus.

Group 2: Vaginal progesterone gel is administered for luteal phase support from second day after insemination until pregnancy testing and is continued in the presence of pregnancy until the 12 weeks of pregnancy.

Goup 3: Patients are undergone intrauterine insemination (IUI) cycles stimulated with gonadotropin without any intervention.

The effect of endometrial injury and luteal phase progesterone support on the pregnancy rate in patients intrauterine insemination (IUI) cycles stimulated with gonadotropin will be compared in terms of biochemical pregnancy rate, clinical pregnancy rate and ongoing pregnancy rate. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02492451
Study type Interventional
Source Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Contact Selcuk Selcuk, MD
Phone +905321630488
Email md_sel@hotmail.com
Status Recruiting
Phase Phase 1
Start date June 2015
Completion date February 2016
View Details
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