Pregnancy Clinical Trial
Official title:
Retinal Nerve Fiber Layer and Macular Thickness Changes During Pregnancy by Optical Coherence Tomography: Prospective, Observational, Nonrandomized Controlled Study
Purpose:
Primary: to prospectively measure Retinal Nerve Fiber Layer (RNFL) and macular thickness
changes during pregnancy by Optical coherence tomography
Secondary: The effect of pregnancy abnormalities on RNFL and macular thickness in
participants who develop systemic or ocular complications during the study period.
There are several known ophthalmic physiologic changes in pregnancy:
1. Refractive Change: progesterone-mediated changes in fluid content partially accounts
for refractive change of lens and cornea; myopic shift of less than 1 D was observed in
in 15% of participating pregnant women
2. Night vision decreased mainly with low serum vitamin A levels in pregnant women.
3. Fall of the IOP in second half of pregnancy (about 10% drop)
4. Corneal changes (increased thickness; decreased sensitivity) = contact lens intolerance
The retina and optic nerve are considered part of central nervous system, the retina and
choroid are highly vascularized. Due to changes in CSF and brain volume, vascular and fluid
changes all over the pregnant woman's body we expect to find changes in RNFL and macular
thickness during pregnancy.
;
Observational Model: Case-Only, Time Perspective: Prospective
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