Pregnancy Clinical Trial
Official title:
Influence of Pregnancy-related Hormonal Fluctuations on Corneal Biomechanics in Humans
The intraocular pressure in the human bulbus requires that the "wall" of the eye shows a
certain (bio)mechanical strength. The human cornea represents the anterior portion of this
wall. Since several years, there is a growing interest in the ophthalmological community for
identifying factors modulating the biomechanical stability of the human cornea. Reasons are
twofold: advances in keratoconus research and the increasing numbers of refractive laser
surgery procedures with (correspondingly) increasing numbers of complications due to
non-respecting the limits of corneal biomechanics.
There is evidence that oestrogen, but also thyroïd hormone changes have a major impact on
corneal biomechanics. A number of recent observational studies have reported on keratoconus
and refractive laser surgery patients with decompensating biomechanics during pregnancy.
Both hormones also show physiological changes during pregnancy and little is known about the
impact of these physiological changes on the human cornea.
The aim of this study is to establish baseline values for physiological changes in the human
cornea during pregnancy.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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