Pregnancy Clinical Trial
Official title:
Pilot Study to Examine Iloprost Can Enhance Human Assisted Reproductive Technology Pregnancy Outcomes.
Verified date | March 2012 |
Source | Fertility Specialists of Houston |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Human fallopian tube secretes high concentration of prostacyclin. Fallopian tube is the site for early embryo development. The effect of prostacyclin on human early embryo development is waiting to be clarified. The study hypothesis is prostacyclin can enhance early embryo development.
Status | Unknown status |
Enrollment | 100 |
Est. completion date | December 2013 |
Est. primary completion date | November 2011 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 39 Years |
Eligibility |
Inclusion Criteria: - ART case Exclusion Criteria: - age < 40 - no pre-implantation genetic diagnosis procedure |
Country | Name | City | State |
---|---|---|---|
United States | Fertility Specialists of Houston | Houston | Texas |
Lead Sponsor | Collaborator |
---|---|
Fertility Specialists of Houston | Origio A/S |
United States,
Battenfeld R, Schuh W, Schöbel C. Studies on reproductive toxicity of iloprost in rats, rabbits and monkeys. Toxicol Lett. 1995 Aug;78(3):223-34. — View Citation
Grunert GM, Dunn RC, Valdes CT, Schenk LM, Mangal RK, Wun WSA: Prostacyclin agonist (Iloprost) enhances human embryo development. Fertility and Sterility 84:S237, 2005
Huang JC, Arbab F, Tumbusch KJ, Goldsby JS, Matijevic-Aleksic N, Wu KK. Human fallopian tubes express prostacyclin (PGI) synthase and cyclooxygenases and synthesize abundant PGI. J Clin Endocrinol Metab. 2002 Sep;87(9):4361-8. — View Citation
Huang JC, Goldsby JS, Wun WS. Prostacyclin enhances the implantation and live birth potentials of mouse embryos. Hum Reprod. 2004 Aug;19(8):1856-60. Epub 2004 Jun 17. — View Citation
Huang JC, Wun WS, Goldsby JS, Matijevic-Aleksic N, Wu KK. Cyclooxygenase-2-derived endogenous prostacyclin enhances mouse embryo hatching. Hum Reprod. 2004 Dec;19(12):2900-6. Epub 2004 Oct 15. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Presence of embryo sac in uterus under ultrasound | The competency of embryo is determined by its ability to implant into endometirum. | 5 weeks after embryo transfer | |
Secondary | The delivery outcome is the secondary outcome measured. | The live birth and the weight and length of baby is examined. | 10 months after embryo transfer |
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