Pregnancy Clinical Trial
Official title:
Iron Supplementation During Pregnancy and Non-Transferrin-Bound Iron (NTBI)
Although the essential role of iron during pregnancy is well established, concerns have been
raised that current iron supplements given routinely during pregnancy may also have harmful
consequences, such as increased oxidative stress and enhanced risks of infection,
pre-eclampsia and impaired glucose regulation. A potential mechanism for the production of
adverse effects is the appearance of non-transferrin-bound iron after oral administration of
iron supplements. Non-transferrin-bound iron is more readily available to pathogens and
could promote injurious free radical reactions that might add to the oxidative stress of
pregnancy.
The present study will determine if oral administration of 60 mg of iron as ferrous sulfate
during the second trimester of pregnancy is followed by the appearance of
non-transferrin-bound iron two hours later. The investigators will examine the influence of
a variety of factors, including iron status and previous use of iron supplements. Detection
of non-transferrin-bound iron after administration of an iron supplement to pregnant women
would be an important new observation that could lead to re-evaluation of current methods of
iron supplementation.
n/a
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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