Hormonal Effects on Pain Perception

Pregnancy Clinical Trial

— HEPP  

Official title:

Hormonal Effects on Pain Perception

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00699595
• Other study ID #: F070721003
• Status: Completed
• Phase: N/A
• First received: June 13, 2008
• Last updated: November 8, 2014
• Start date: September 2008
• Est. completion date: November 2014

Study information

• Verified date: November 2014
• Source: University of Alabama at Birmingham
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

To investigate if labor pain is affected by mother's hormone levels.

The hormonal effects of pregnancy are well documented. Although differences in pain sensitivity between women and men are partly attributable to social conditioning and to psychosocial factors, many laboratory studies of humans have described sex differences in sensitivity to noxious stimuli, suggesting that biological mechanisms underlie such differences. Some animal studies have suggested that sensitivity to pain decreases during pregnancy because of the progressive activation of endogenous pain inhibitory systems. This effect may be mediated by pregnancy-associated hormones, in particular progesterone.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: November 2014
• Est. primary completion date: November 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 19 Years to 45 Years

Eligibility

Inclusion Criteria:

• healthy pregnant women at term (>37GA)

Exclusion Criteria:

• chronic pain

• regular analgesic medication

• severe cardiopulmonary problems

• very difficult intravenous access

• advanced labor

• precipitous delivery

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Pregnancy
• Pregnancy Associated Analgesia
• Progesterone Levels

Locations

Country	Name	City	State
United States	University of Alabama at Birmingham	Birmingham	Alabama

Sponsors (1)

Lead Sponsor	Collaborator
University of Alabama at Birmingham

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in heat pain threshold and tolerance		1 month	No