Pregnancy Clinical Trial
Official title:
Facilitating Informed for Prenatal Testing: The Role of Ambivalence
This study will examine how women think and feel about prenatal testing (amniocentesis and
chorionic villus sampling), how those thoughts and feelings change over time, and how they
contribute to the decision whether or not to undergo prenatal testing.
Prenatal diagnostic testing is offered to pregnant women at increased risk of carrying a baby
affected with a genetic or chromosomal abnormality. Although these tests are well
established, standard-of-care procedures, much remains unknown about how best to ensure that
women make decisions about whether or not to undergo testing that are consistent with their
beliefs and values. This study will explore the extent to which women are ambivalent about
prenatal testing and determine how they might benefit from counseling aimed at improving the
quality of their decision-making.
Women 18 years of age and older who are scheduled for a prenatal genetics visit at clinics in
Baltimore, MD; Minneapolis, MN; Binghamton, NY; Salt Lake City, UT; Washington, DC; and
Bellevue, WA, and are at increased risk for having a baby with trisomy 21 (Down syndrome) may
be eligible for this study.
Participants complete two short questionnaires and a telephone interview about their thoughts
and feelings regarding prenatal testing. The first two surveys examine the women's thoughts
and feelings before and after prenatal counseling. Both are completed at the prenatal
clinic-one before and one after the counseling session. The third survey is done by telephone
a few weeks after the prenatal visit to find out if the participant did or did not have
prenatal testing and learn about her thoughts and feelings regarding her decision.
The proposed study seeks to estimate the prevalence of ambivalence about undergoing diagnostic testing among women referred for prenatal genetic counseling, and the predictors and decisional consequences of such ambivalence. Women seen at six different U.S. prenatal clinics for genetic counseling at increased risk for carrying a fetus with trisomy 21 [N=240] will be asked to complete a questionnaire on three occasions: prior to counseling; immediately after counseling, and later by telephone. These data will be used to describe the extent to which a sample of U.S. women referred for prenatal counseling based upon maternal age or results of a screening test are ambivalent about prenatal testing and might benefit from interventions aimed at improving the quality of decision-making. ;
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