Pregnant Women Who Requested Epidural Analgesia in the Early Stage of Labor Clinical Trial
Official title:
A Randomized Controlled Comparison of Different Dose Combinations of Bupivacaine and Sufentanil on Epidural Analgesia Onset Time and Adverse Reactions During Labor
This study aimed to compare the effects of three commonly used combination doses on the onset time and adverse reactions.
Epidural block is widely used as an analgesic method during labor. During epidural
anaesthesia, lipophilic opioids such as sufentanil, are often combined with local anesthetics
to prolong the duration of analgesia and improve the analgesic effect. However, dose
combinations of local anesthetics and opioids, especially in the initial loading dose, vary
greatly from hospital to hospital and often depend upon the different routines adopted by
anesthesiologists. In clinical practice, there are still some controversy about opioid dose
selection in terms of analgesic onset time and adverse reactions.
In this study, three combinations of bupivacaine and sufentanil were chosen, commonly used in
the clinic, and extended the observation period to 24 hours after delivery. We hypothesized
that increasing the concentration of local anesthetic, rather than increasing the dose of
sufentanil, would achieve a faster analgesic effect with minimal adverse effects on the
mother and fetus. To test our hypothesis, our primary outcome was to compare the times of
analgesia onset of the three combinations, and the secondary outcomes were to compare the
effects on maternal and infant adverse reactions.
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