Pregnancy Clinical Trial
Official title:
Dual Trigger With Gonadotropin-releasing Hormone Agonist (GnRHa) and Human Chorionic Gonadotropin (hCG) to Optimize ICSI Reproductive Outcomes
The use of antagonist controlled ovarian stimulation protocols has allowed the use of GnRH
agonist to be used for final oocyte maturation. The use of GnRH agonist as ovulation trigger
has been shown to reduce the risks for ovarian hyperstimulation syndrome (OHSS), but its
sole use results in reduced embryo implantation due to luteal phase insufficiency. The
combination of GnRH agonist and variable doses of hCG for final oocyte maturation has been
shown to overcome the luteal phase insufficiency effecting endometrial receptivity.
In this study the investigators will test the hypothesis that using GnRH agonist (0.2mg
Triptorelin) and a full dose of hCG (6500IU Ovitrelle) for final oocyte maturation in
normoresponders will increase oocyte maturity, embryo quality and embryo implantation and
reduce ovarian hyperstimulation syndrome, as compared to the traditional hCG (full dose)
alone trigger.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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