Freeze All Strategy Versus Fresh Embryo Transfer After GnRH Analogue Trigger

Pregnancy Related Clinical Trial

Official title: Freeze All Strategy Versus Fresh Embryo Transfer After GnRH Analogue Trigger

Status Completed

Clinical Trial Summary

Ovarian hyperstimulation syndrome (OHSS) is one of the most dangerous complications of assisted reproduction technology (ART), described in approximatively 3 to 10% of stimulation cycles although an underestimation of the real incidence has been suggested.

The use in clinical practice of GnRH antagonist has made it possible to perform the trigger with GnRH analogues, with the advantage of considerably reducing the risk of OHSS.

Clinical Trial Description

The main concerns about the trigger with analogue are about obstetric outcomes, since it may increase the Abortion Rate (AR) and reduce the Ongoing Pregnancy Rate (OPR) due to luteal phase deficiency, and on the other hand about oocyte quality and competence.

While in order to maximize the chance of pregnancy at fresh embryo transfer after GnRHa trigger, several studies have focused on the importance of luteal phase support, other authors suggest that the best strategy is freeze-all: cryopreservation of all the obtained embryos and subsequent single embryo transfers.

However, data about oocyte quality, retrieval rate, pregnancy rate and reduced occurrence of complications such as OHSS, especially on the very first embryo transfer, are still scarce. ;

Related Conditions & MeSH terms

• Ovarian Hyperstimulation Syndrome
• Pregnancy Related

• NCT number: NCT05362734
• Study type: Observational
• Source: Istituto Clinico Humanitas
• Status: Completed
• Start date: January 1, 2012
• Completion date: December 31, 2020